Dicyclohexylcarbodiimide → HCID 18603232, compound

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Reaction Steps

1.55 g (0.014 mole) of glycinamide hydrochloride is dissolved in 50 ml of DMF by warming to 50°. The solution is cooled to 25° and 2 ml of triethylamine is added, followed by 1.89 g of hydroxybenztriazole, 3.5 g (0.014 mol) of BOC-D-leucine H2O and lastly, 2.9 g (0.014 mol) of dicyclohexylcarbodiimide. The mixture is stirred two days at 25° and then evaporated in vacuo to an oil. The oil is dissolved in 200 ml EtOAC, 50 ml CHCl3. The organic solution is washed with water, 20% citric acid solution, water, 10% Na2CO3 solution. The EtOAc solution is dried over MgSO4 and the solvent removed in vacuo to a glass, 3.7 g (93%).

Provenance & Evidence