HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1982789Generated: November 1, 2026
Water → 2-{[1-(Phenylsulfonyl)-1H-indole-4-yl]oxy}ethylazide
https://huagongshe.com/reaction/1982789
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 4-(2-Chloroethoxy)-1-(phenylsulfonyl)-1H-Indole | HCID 10404724 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-{[1-(Phenylsulfonyl)-1H-indole-4-yl]oxy}ethylazide | HCID 12018438 | — |
Reaction Steps
A suspension of 4-(2-chloroethoxy)-1-(phenylsulfonyl)-1H-indole (3.35 g, 10 mmol) and sodium azide (1.95 g, 30 mmol) in anhydrous dimethylformamide is stirred under nitrogen for 20 hr at 60° C., poured into water and extracted with diethyl ether. The extracts are combined, washed sequentially with 1N HCl, H2O and saturated NaCl, dried over MgSO4 and concentrated in vacuo to afford the title product as an off-white solid, 3.3 g (96%), identified by NMR and mass spectral analyses.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07541358B2 |
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| Source dataset | uspto-grants-2009_06 |
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| ORD ID | ord-7ea0f066c6c249dfaf0dfbd177a60da6 |
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| Source note | uspto-grants-2009_06 |
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