Ammonia → HCID 21909291, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of methyl 4-(4-ethylbenzyl)-3-hydroxybenzoate (0.20 g) and 28% aqueous ammonia solution (6 mL) in ethanol (3 mL) was added ammonium chloride (0.079 g), and the mixture was stirred at 100° C. in a sealed tube for 14 hours. The reaction mixture was concentrated, and water was added to the residue. The mixture was extracted with ethyl acetate, and the organic layer was dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure, and to the residue was added a mixture (10/1) of dichloromethane and methanol. Insoluble materials were collected and dried to give 4-(4-ethylbenzyl)-3-hydroxybenzamide (0.065 g).

Provenance & Evidence