HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Dimethylphenol → 2-(4-Methoxybenzyl)-3,5-dimethylphenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Dimethylphenol | HCID 7948 | — |
| Reactant | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Product | 2-(4-Methoxybenzyl)-3,5-dimethylphenol | HCID 12085603 | — |
Reaction Steps
To 3,5-dimethylphenol (12 g) were added lithium hydroxide monohydrate (4.2 g) and 4-methoxybenzyl chloride (14 mL) at 85° C., and the mixture was stirred for 1.5 hours. The reaction mixture was cooled to room temperature and purified by column chromatography on silica gel (eluent: dichloromethene) to give 2-(4-methoxybenzyl)-3,5-dimethylphenol (5.1 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541341B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-44cdeee92fdb4fb7b1084f1199bf1eec |
| Source note | uspto-grants-2009_06 |