4-Fluorobenzylamine → 3-(4-Fluorobenzylamino)-4-nitropyridine

HRID 1982898Notes

Reaction equation

Br[C:2]1[CH:3]=[N+:4]([O-])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[F:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17][NH2:18])=[CH:15][CH:14]=1>>[F:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17][NH:18][C:2]2[CH:3]=[N:4][CH:5]=[CH:6][C:7]=2[N+:8]([O-:10])=[O:9])=[CH:15][CH:14]=1

Participants

Reactant 2

HCID 673264-Fluorobenzylamine

HCID 5485213-Bromo-4-nitropyridine N-oxide

Product 1

HCID 156147143-(4-Fluorobenzylamino)-4-nitropyridineYield 35.8%

Procedure

In accordance with the same procedures as in Preparation 2, except for using 3-bromo-4-nitropyridin-N-oxide prepared in Step 2 of Preparation 1 and 4-fluorobenzylamine, the titled compound was obtained as a yellow solid. (Yield: 35.8%)

Workup

customIn accordance with the same procedures as in Preparation 2

Sources & evidence

ORD record: ord-bc4481188710495c83fe4ca54a31aff7
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07541366B2

Reaction notes

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