HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(Phenylsulfonyl)-4-piperazin-1-yl-1H-indole Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | t-butyl 4-(1-benzenesulfonyl-1H-indol-4-yl)piperazine-1-carboxylate | HCID 22015366 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(Phenylsulfonyl)-4-piperazin-1-yl-1H-indole Hydrochloride | HCID 10270968 | 99% |
Reaction Steps
A portion of the t-butyl 4-(1-benzenesulfonyl-1H-indol-4-yl)piperazine-1-carboxylate (0.85 g) is stirred in a mixture of 4N HCl and dioxane at room temperature for 2 hrs and filtered. The filtercake is dried to give the title product as a while solid, 0.64 g (99% yield) mp 60° C. identified by mass spectral and NMR analyses.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541370B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-f165fbf7df92412f96822d2391b04c7f |
| Source note | uspto-grants-2009_06 |