Dichloromethane → HCID 17987997, compound

Participants

Reaction Steps

4-amino-5-chloro-2-methoxybenzoic acid (60 mg, 0.30 mmol) is dissolved in DCM and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI) (64 mg, 0.30 mmol) is added followed by the addition of Intermediate 3 (130 mg, 0.28 mmol). The reaction is stirred at room temperature for overnight and the reaction is concentrated to dryness and purified on a 10 gram silica gel column using ethyl acetate/heptane (35%/65%) to give 60 mg of 1-{4-[8-(4-Amino-5-chloro-2-methoxy-benzoyl)-8-aza-bicyclo[3.2.1]oct-3-ylmethyl]-phenyl}-3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-urea, Compound A1441, Example 6. m/z(LCMS) M+1=636, RT=3.47 minutes.

Provenance & Evidence