Hydrochloric Acid → HCID 178524258, compound

Participants

Reaction Conditions

Reaction Steps

Compound 108 (1.5 g, 3.57 mmol) was suspended in a 10% aqueous sodium hydroxide solution (20 mL) and MeOH (10 mL). The suspension was heated to 80° C. for five hours. The reaction mixture was cooled to room temperature then acidified with 1M hydrochloric acid. The resulting precipitate was collected and the filtrate was concentrated to remove the residual MeOH. Additional precipitate was collected and combined with the previous portion and dried to afford Compound 17 (1.2 g, 83%) as a grey solid. 1H NMR (400 MHz, CD3OD) δ 9.81 (s, 1H), 9.14 (s, 1H), 8.89 (m, 2H), 8.61 (d, 1H, J=8.4 Hz), 8.23 (m, 2H), 8.06 (m, 2H), 8.03 (d, 1H, J=8.0 Hz), 7.44 (t, 1H, J=8.0 Hz); MS (ESI) m/z: 407 (M+H+).

Provenance & Evidence