HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → HCID 178457677, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 178524258 | HCID 178524258 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178457677 | HCID 178457677 | 33.5% |
Reaction Steps
A mixture of Compound 17 (25 mg, 0.06 mmol), isopropylamine (11 μl, 0.12 mmol), HATU (23.4 mg, 0.06 mmol) and DIPEA (35 μl, 0.48 mmol) in DMSO (1 mL) was stirred at room temperature overnight. The solution was diluted with MeOH (0.4 mL) and purified by Gilson HPLC (10% to 90% of 0.1% TFA in ACN/0.1% TFA in H2O) to yield Compound 18 (9 mg, 33%) as a pale yellow solid. 1H NMR (300 MHz, CD3OD) δ 9.79 (s, 1H), 8.96 (s, 1H), 8.84 (s, 1H), 8.78 (s, 1H), 8.57 (d, 1H, J=8.4 Hz), 8.16 (m, 2H), 8.04 (m, 1H), 7.87 (d, 1H, J=7.8 Hz), 7.69 (d, 1H, J=6.9 Hz), 7.32 (t, 1H, J=7.8 Hz), 3.99 (m, 1H), 0.86 (d, 6H, J=6 Hz); MS (ESI) m/z: 448 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541367B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-aa7779f4834045c191aebd9e07808710 |
| Source note | uspto-grants-2009_06 |