Thionyl Chloride → 3-i-propyl-1-(chloromethyl)-1H-pyrazole hydrochloride

HRID 1982994Notes

Reaction equation

HRID 1982994 reaction equation
[CH:1]([C:4]1[CH:8]=[CH:7][N:6]([CH2:9]O)[N:5]=1)([CH3:3])[CH3:2].S(Cl)([Cl:13])=O>ClCCl>[ClH:13].[CH:1]([C:4]1[CH:8]=[CH:7][N:6]([CH2:9][Cl:13])[N:5]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 23149190[3-(propan-2-yl)-1H-pyrazol-1-yl]methanol

Product 1

HCID 231491783-i-propyl-1-(chloromethyl)-1H-pyrazole hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.28 g of 3-i-propyl-1H-pyrazole-1-ylmethanol was dissolved to 20 ml of dichloromethane. 2 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 1.58 g of 3-i-propyl-1-(chloromethyl)-1H-pyrazole hydrochloride.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-c6f5aa9115c248108b26d7c6ed139dad
Source dataset
uspto-grants-2009_06
Patent number
US07541374B2

Reaction notes

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