Thionyl Chloride → 1-(chloromethyl)-3-(trifluoromethyl)-1H-pyrazole

HRID 1983000Notes

Reaction equation

HRID 1983000 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:7]=[CH:6][N:5]([CH2:8]O)[N:4]=1.S(Cl)([Cl:14])=O>ClCCl>[Cl:14][CH2:8][N:5]1[CH:6]=[CH:7][C:3]([C:2]([F:11])([F:10])[F:1])=[N:4]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 23149202[3-(trifluoromethyl)-1H-pyrazol-1-yl]methanol

Product 1

HCID 196193331-(chloromethyl)-3-(trifluoromethyl)-1H-pyrazole

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.33 g of 3-(trifluoromethyl)-1H-pyrazole-1-ylmethanol was dissolved to 40 ml of dichloromethane. 2.7 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 1.44 g of 1-(chloromethyl)-3-(trifluoromethyl)-1H-pyrazole.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-945e5508e1e64fcd81ee8f6e1d218a32
Source dataset
uspto-grants-2009_06
Patent number
US07541374B2

Reaction notes

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