Sodium Hydroxide → HCID 178440430, compound

Temperature

0 °C

1.10 g of 3-i-propyl-1H-pyrazole was suspended in 20 ml of water, and 1.6 g of 50% aqueous solution of sodium hydroxide was added to it. The mixture was cooled to 0° C., and then 1.76 g of bromine was added to the mixture, followed by stirring at room temperature for 5 hours. The reaction mixture was extracted by ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 1.88 g of 4-bromo-3-i-propyl-1H-pyrazole.

1. extractionThe reaction mixture was extracted by ethyl acetate
2. washThe organic layer was washed with water
3. dry with materialdried over anhydrous magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated under reduced pressure

ORD record

ord-ca3dee36318e4e3c8aa5936d56bf119b

Source dataset

uspto-grants-2009_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07541374B2