Thionyl Chloride → 4-bromo-3-i-propyl-1-(chloromethyl)-1H-pyrazole hydrochloride

HRID 1983009Notes

Reaction equation

HRID 1983009 reaction equation
[Br:1][C:2]1[C:3]([CH:9]([CH3:11])[CH3:10])=[N:4][N:5]([CH2:7]O)[CH:6]=1.S(Cl)([Cl:14])=O>ClCCl>[ClH:14].[Br:1][C:2]1[C:3]([CH:9]([CH3:11])[CH3:10])=[N:4][N:5]([CH2:7][Cl:14])[CH:6]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 231492074-bromo-3-i-propyl-1H-pyrazole-1-ylmethanol

Product 1

HCID 231491844-bromo-3-i-propyl-1-(chloromethyl)-1H-pyrazole hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.29 g of 4-bromo-3-i-propyl-1H-pyrazole-1-ylmethanol was dissolved to 20 ml of dichloromethane. 2 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 1.28 g of 4-bromo-3-i-propyl-1-(chloromethyl)-1H-pyrazole hydrochloride.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-9f9cc6fdf1184ec1ac53d8a1a69956e6
Source dataset
uspto-grants-2009_06
Patent number
US07541374B2

Reaction notes

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