Thionyl Chloride → 3-t-butyl-4-chloro-1-(chloromethyl)-1H-pyrazole hydrochloride

HRID 1983015Notes

Reaction equation

HRID 1983015 reaction equation
[C:1]([C:5]1[C:9]([Cl:10])=[CH:8][N:7]([CH2:11]O)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].S(Cl)([Cl:15])=O>ClCCl>[ClH:10].[C:1]([C:5]1[C:9]([Cl:10])=[CH:8][N:7]([CH2:11][Cl:15])[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 231491223-t-butyl-4-chloro-1H-pyrazole-1-ylmethanol

Product 1

HCID 231491483-t-butyl-4-chloro-1-(chloromethyl)-1H-pyrazole hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.82 g of 3-t-butyl-4-chloro-1H-pyrazole-1-ylmethanol was dissolved to 45 ml of dichloromethane. 3.4 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 0.98 g of 3-t-butyl-4-chloro-1-(chloromethyl)-1H-pyrazole hydrochloride.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-4af758ea72c443638fe3eb0441d71b34
Source dataset
uspto-grants-2009_06
Patent number
US07541374B2

Reaction notes

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