Formaldehyde → 4-bromo-3-(trifluoromethyl)-1H-pyrazole-1-ylmethanol

Temperature

140 °C

The mixture of 3.38 g of 4-bromo-3-(trifluoromethyl)-1H-pyrazole and 0.66 g of paraformaldehyde was stirred at 140° C. for 5 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. The mixture was filtered. Hexane was added to the residue obtained by concentration of the filtrate under reduced pressure, as a result, a crystal was formed. The crystal was collected to obtain 3.28 g of 4-bromo-3-(trifluoromethyl)-1H-pyrazole-1-ylmethanol.

1. temperatureAfter the reaction mixture was cooled to room temperature
2. filtrationThe mixture was filtered
3. additionHexane was added to the residue
4. customobtained by concentration of the filtrate under reduced pressure, as a result
5. customa crystal was formed
6. customThe crystal was collected

ORD record

ord-f662bb82c3de4544a643ac2e08139b7e

Source dataset

uspto-grants-2009_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07541374B2