反应详情

温度

140 °C

The mixture of 3.38 g of 4-bromo-3-(trifluoromethyl)-1H-pyrazole and 0.66 g of paraformaldehyde was stirred at 140° C. for 5 hours. After the reaction mixture was cooled to room temperature, acetone was added to the reaction mixture. The mixture was filtered. Hexane was added to the residue obtained by concentration of the filtrate under reduced pressure, as a result, a crystal was formed. The crystal was collected to obtain 3.28 g of 4-bromo-3-(trifluoromethyl)-1H-pyrazole-1-ylmethanol.

1. temperatureAfter the reaction mixture was cooled to room temperature
2. filtrationThe mixture was filtered
3. additionHexane was added to the residue
4. customobtained by concentration of the filtrate under reduced pressure, as a result
5. customa crystal was formed
6. customThe crystal was collected