Thionyl Chloride → 1-(chloromethyl)-3,5-dimethyl-1H-pyrazole hydrochloride

HRID 1983019Notes

Reaction equation

HRID 1983019 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[N:4]([CH2:8]O)[N:3]=1.S(Cl)([Cl:12])=O>ClCCl>[ClH:12].[Cl:12][CH2:8][N:4]1[C:5]([CH3:7])=[CH:6][C:2]([CH3:1])=[N:3]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 963933,5-Dimethylpyrazol-1-methanol

Product 1

HCID 136927271-(chloromethyl)-3,5-dimethyl-1H-pyrazole hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.63 g of 3,5-dimethyl-1H-pyrazole-1-ylmethanol was dissolved to 25 ml of dichloromethane. 1.2 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 0.93 g of 1-(chloromethyl)-3,5-dimethyl-1H-pyrazole hydrochloride.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-571f806eb95f40789a06bdbe4b8b9f32
Source dataset
uspto-grants-2009_06
Patent number
US07541374B2

Reaction notes

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