HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → methyl 1-(chloromethyl)-1H-pyrazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | methyl 1-(hydroxymethyl)-1H-pyrazole-4-carboxylate | HCID 23149172 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | methyl 1-(chloromethyl)-1H-pyrazole-4-carboxylate | HCID 7017727 | — |
Reaction Steps
1.38 g of 1-(hydroxymethyl)-4-methoxycarbonyl-1H-pyrazole was dissolved to 10 ml of dichloromethane. 1 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 1.59 g of 1-(chloromethyl)-4-methoxycarbonyl-1H-pyrazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541374B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-65e58aff5c4a475398d6318ae059338a |
| Source note | uspto-grants-2009_06 |