Formaldehyde → HCID 23149171, compound

HRID 1983027Notes

Reaction equation

HRID 1983027 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][NH:5][N:4]=1.[CH2:15]=[O:16]>CC(C)=O>[OH:16][CH2:15][N:5]1[CH:6]=[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:3]([C:2]([F:1])([F:13])[F:14])=[N:4]1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 178469923HCID 178469923, compound

Product 1

HCID 23149171HCID 23149171, compoundYield 93.7%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
150 °C

Procedure

The mixture of 2.08 g of 3-(trifluoromethyl)-4-ethyoxycarbonyl-1H-pyrazole and 0.66 g of paraformaldehyde was stirred at 150° C. for 4 hours. After the reaction mixture was cooled to room temperature, acetone was added. After the mixture was filtered, the filtrate was concentrated under reduced pressure to obtain 2.23 g of 1-(hydroxymethyl)-3-(trifluoromethyl)-4-ethoxycarbonyl-1H-pyrazole.

Workup

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationAfter the mixture was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-16e3541476894d3589473c20a3d5b513
Source dataset
uspto-grants-2009_06
Patent number
US07541374B2

Reaction notes

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