Thionyl Chloride → 1-(chloromethyl)-3-(pentafluoroethyl)-1H-pyrazole

HRID 1983043Notes

Reaction equation

HRID 1983043 reaction equation
[F:1][C:2]([F:14])([C:7]1[CH:11]=[CH:10][N:9]([CH2:12]O)[N:8]=1)[C:3]([F:6])([F:5])[F:4].S(Cl)([Cl:17])=O>ClCCl>[Cl:17][CH2:12][N:9]1[CH:10]=[CH:11][C:7]([C:2]([F:14])([F:1])[C:3]([F:6])([F:5])[F:4])=[N:8]1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 231491363-(pentafluoroethyl)-1H-pyrazole-1-ylmethanol

Product 1

HCID 231491811-(chloromethyl)-3-(pentafluoroethyl)-1H-pyrazole

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.98 g of 3-(pentafluoroethyl)-1H-pyrazole-1-ylmethanol was dissolved to 20 ml of dichloromethane. 1.5 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 2.01 g of 1-(chloromethyl)-3-(pentafluoroethyl)-1H-pyrazole.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-99c8ffda75f04edc8a1dbea01c0c1090
Source dataset
uspto-grants-2009_06
Patent number
US07541374B2

Reaction notes

Loading…