Thionyl Chloride → 4-bromo-1-(chloromethyl)-3-(pentafluoroethyl)-1H-pyrazole

HRID 1983046Notes

Reaction equation

HRID 1983046 reaction equation
[Br:1][C:2]1[C:3]([C:9]([F:15])([F:14])[C:10]([F:13])([F:12])[F:11])=[N:4][N:5]([CH2:7]O)[CH:6]=1.S(Cl)([Cl:18])=O>ClCCl>[Br:1][C:2]1[C:3]([C:9]([F:15])([F:14])[C:10]([F:13])([F:12])[F:11])=[N:4][N:5]([CH2:7][Cl:18])[CH:6]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 231491334-bromo-3-(pentafluoroethyl)-1H-pyrazole-1-ylmethanol

Product 1

HCID 231491944-bromo-1-(chloromethyl)-3-(pentafluoroethyl)-1H-pyrazole

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

6.49 g of 4-bromo-3-(pentafluoroethyl)-1H-pyrazole-1-ylmethanol was dissolved to 60 ml of dichloromethane. 3.2 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 6.84 g of 4-bromo-1-(chloromethyl)-3-(pentafluoroethyl)-1H-pyrazole.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-96d77e08646f48fbbae403a54c833d69
Source dataset
uspto-grants-2009_06
Patent number
US07541374B2

Reaction notes

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