Thionyl Chloride → HCID 23149199, compound

Participants

Reaction Conditions

Reaction Steps

The obtained 1-hydroxymethyl-4-trifluoromethyl-3-ethoxycarbonyl-1H-pyrole was dissolved to 3 ml of chloroform, and 4 ml of thionyl chloride was added, followed by refluxing for 30 minutes. After the reaction mixture was cooled to 0° C., it was poured into ice-water. The mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous solution of sodium hydrogen carbonate, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated under reduced pressure to obtain 225 mg of 1-chloromethyl-4-trifluoromethyl-3-ethoxycarbonyl-1H-pyrole.

Provenance & Evidence