HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → HCID 18446929, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | 2-[1-(3-Chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]-8-methyl-6-nitro-4H-3,1-benzoxazin-4-one | HCID 69064483 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 18446929 | HCID 18446929 | 14.3% |
Reaction Steps
Isopropyl amine (0.35 mL, 4.11 mmol) was added to a solution of 619 mg (1.37 mmol) of the product of Step B in dioxane (8 mL) at 25° C. After being stirred overnight, the resulting heterogenous mixture was concentrated and the residue was triturated with methanol (10 mL). Filtration gave 100 mg of the title product. The filtrate was concentrated and the resulting residue was triturated with diethyl ether. Filtration of the resulting solid provided an additional 320 mg of the title product, m.p. 170-172° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541377B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-884240302a6a4e819bbe11983f6cd039 |
| Source note | uspto-grants-2009_06 |