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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 19831Generated: October 30, 2026

Trimethyl borate → [4-(Difluoromethyl)phenyl]boronic acid

https://huagongshe.com/reaction/19831

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrimethyl borateHCID 8470—
Reactant1-(Difluoromethyl)-4-iodobenzeneHCID 46311737—
ReactantHCID 178418918HCID 178418918—
Product[4-(Difluoromethyl)phenyl]boronic acidHCID 20777176—

Reaction Steps

In a departure from the procedure described above the compound is prepared from 4-difluoromethyl-1-iodo-benzene (prepared from 4-iodobenzaldehyde using diethylaminosulfurtrifluoride (DAST) in dichloromethane) using iPrMgCl to generate the arylmetal compound and trapping this intermediate with trimethyl borate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07745414B2
Source datasetuspto-grants-2010_06
ORD IDord-087999f7e0d549caa6d74fe79b97b3d8
Source noteuspto-grants-2010_06