3-Methanesulfonylbenzoic acid → HCID 16722697, compound

HRID 1983111Notes

Reaction equation

HRID 1983111 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]([NH:15][NH2:16])=[O:14].[CH3:17][S:18]([C:21]1[CH:22]=[C:23]([CH:27]=[CH:28][CH:29]=1)[C:24](O)=O)(=[O:20])=[O:19]>>[CH3:17][S:18]([C:21]1[CH:22]=[C:23]([C:24]2[O:14][C:13]([C:3]3[C:4]([C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=4)=[N:5][O:6][C:2]=3[CH3:1])=[N:15][N:16]=2)[CH:27]=[CH:28][CH:29]=1)(=[O:19])=[O:20]

Participants

3

Reactant 2

HCID 2203803-Methanesulfonylbenzoic acidHCID 7279245-Methyl-3-phenyl-4-isoxazolecarbohydrazide

Product 1

HCID 16722697HCID 16722697, compoundYield 13%

Procedure

As described for example 2, 5-methyl-3-phenyl-isoxazole-4-carboxylic acid hydrazide (200 mg, 0.92 mmol) was converted using 3-(methylsulfonyl)-benzoic acid instead of o-toluic acid to the title compound (SiO2, heptane:ethyl acetate:dichloromethane=50:30:20 to 20:60:20, 44 mg, 13%) which was obtained as a white solid. MS: m/e=382.1 [M+H]+.

Sources & evidence

ORD record
ord-81937b5bc0824b2ebf696868dca2957d
Source dataset
uspto-grants-2009_06
Patent number
US07541372B2

Reaction notes

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