2-Methylimidazole → HCID 16722854, compound

HRID 1983137Notes

Reaction equation

F[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([C:13]3[C:14]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)=[N:15][O:16][C:17]=3[CH3:18])=[N:11][N:12]=2)=[CH:4][CH:3]=1.[CH3:25][C:26]1[NH:27][CH:28]=[CH:29][N:30]=1>>[CH3:25][C:26]1[N:27]([C:2]2[CH:7]=[CH:6][C:5]([C:8]3[O:9][C:10]([C:13]4[C:14]([C:19]5[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=5)=[N:15][O:16][C:17]=4[CH3:18])=[N:11][N:12]=3)=[CH:4][CH:3]=2)[CH:28]=[CH:29][N:30]=1

Participants

Reactant 2

HCID 127492-Methylimidazole

HCID 16722749HCID 16722749, compound

Product 1

HCID 16722854HCID 16722854, compoundYield 46%

Procedure

As described for example 47, 2-(4-fluoro-phenyl)-5-(5-methyl-3-phenyl-isoxazol-4-yl)-[1,3,4]oxadiazole (200 mg, 0.62 mmol) was converted using 2-methyl-imidazole instead of piperidine to the title compound (110 mg, 46%) which was obtained a light-brown waxy solid. MS: m/e=384.0 [M+H]+.

Sources & evidence

ORD record: ord-9bcb79b9814746cc9cbaca6a9cedffb9
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07541372B2

Reaction notes

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