Piperazine → HCID 16722904, compound

Participants

Reaction Steps

As described for example 26, 2-(4-fluoro-2-methoxy-phenyl)-5-(5-methyl-3-phenyl-isoxazol-4-yl)-[1,3,4]oxadiazole (200 mg, 0.57 mmol) was converted using piperazine instead of thiomorpholine to the title compound (SiO2, dichloromethane:(dichloromethane: methanol:ammonia=70:27:3)=92:2 to 50:50, 40 mg, 17%) which was obtained as an off-white solid. MS: m/e=418.3 [M+H]+.

Provenance & Evidence