5-Methyl-3-phenyl-4-isoxazolecarbohydrazide → HCID 16722908, compound

HRID 1983149Notes

Reaction equation

HRID 1983149 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]([NH:15][NH2:16])=[O:14].[C:17]([O:28][CH3:29])(=[O:27])[C:18]1[CH:26]=[CH:25][C:21]([C:22]([O-])=O)=[CH:20][CH:19]=1>>[CH3:29][O:28][C:17](=[O:27])[C:18]1[CH:26]=[CH:25][C:21]([C:22]2[O:14][C:13]([C:3]3[C:4]([C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=4)=[N:5][O:6][C:2]=3[CH3:1])=[N:15][N:16]=2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 7279245-Methyl-3-phenyl-4-isoxazolecarbohydrazideHCID 36144541,4-Benzenedicarboxylic acid, methyl ester

Product 1

HCID 16722908HCID 16722908, compoundYield 60%

Procedure

As described for example 2, 5-methyl-3-phenyl-isoxazole-4-carboxylic acid hydrazide (2.00 g, 9.21 mmol) was converted using mono-methyl terephthalate instead of o-toluic acid to the title compound (1.98 mg, 60%) which was obtained as a colorless liquid. MS: m/e=310.3 [M+H]+.

Sources & evidence

ORD record
ord-dd0ed02be39249efb3a3a4b672e2b076
Source dataset
uspto-grants-2009_06
Patent number
US07541372B2

Reaction notes

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