2,4,5-Trifluorobenzoic acid → HCID 16722420, compound

HRID 1983184Notes

Reaction equation

HRID 1983184 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]([NH:15][NH2:16])=[O:14].[F:17][C:18]1[CH:26]=[C:25]([F:27])[C:24]([F:28])=[CH:23][C:19]=1[C:20](O)=O>>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]1[O:14][C:20]([C:19]2[CH:23]=[C:24]([F:28])[C:25]([F:27])=[CH:26][C:18]=2[F:17])=[N:16][N:15]=1

Participants

3

Reactant 2

HCID 5211702,4,5-Trifluorobenzoic acidHCID 7279245-Methyl-3-phenyl-4-isoxazolecarbohydrazide

Product 1

HCID 16722420HCID 16722420, compoundYield 46%

Procedure

As described for example 2, 5-methyl-3-phenyl-isoxazole-4-carboxylic acid hydrazide (4.18 g, 19.2 mmol) was converted using 2,4,5-trifluorobenzoic acid instead of o-toluic acid to the title compound (3.16 g, 46%) which was obtained as a white solid. MS: m/e=358.1 [M+H]+.

Sources & evidence

ORD record
ord-bc041917eb5d4a6185723156fe35857d
Source dataset
uspto-grants-2009_06
Patent number
US07541372B2

Reaction notes

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