HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 2-(2,3,4-Trimethoxybenzyloxy)-1-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| Reactant | (2,3,4-Trimethoxyphenyl)methanol | HCID 123571 | — |
| Reactant | 2-(2,3,4-Trimethoxybenzyloxy)aniline | HCID 66998842 | — |
| Product | N-[2-(2,3,4-trimethoxybenzyloxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732707 | 65% |
| Product | 2-(2,3,4-Trimethoxybenzyloxy)-1-nitrobenzene | HCID 66998910 | 72% |
Reaction Steps
2-(2,3,4-Trimethoxybenzyloxy)-1-nitrobenzene (0.46 g, 72%) was prepared from 2,3,4-trimethoxybenzyl alcohol (0.35 ml, 2.0 mmol) and 1-fluoro-2-nitrobenzene (0.21 ml, 2.0 mmol) following the general procedure G. This was reduced to 2-(2,3,4-trimethoxybenzyl-oxy)aniline (0.26 g, 65%) following the general procedure B. N-[2-(2,3,4-trimethoxybenzyl-oxy)phenyl]-N′-(thiazol-2-yl)urea (240 mg, 65%) was prepared from 2-(2,3,4-trimethoxybenzyloxy)aniline (0.26 g, 0.9 mmol) and 2-aminothiazole (140 mg, 1.4 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541373B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-d903e9394e1e41a0a17f0b27147cddba |
| Source note | uspto-grants-2009_06 |