HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 1-(4-Chlorophenoxy)-2-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | 4-Chlorophenol | HCID 4684 | — |
| Reactant | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| Reactant | 2-(4-Chlorophenoxy)aniline | HCID 76010 | — |
| Product | 1-(4-Chlorophenoxy)-2-nitrobenzene | HCID 3016050 | 71% |
| Product | N-[2-(4-Chlorophenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732782 | 62% |
Reaction Steps
2-(4-Chlorophenoxy)-1-nitrobenzene (0.88 g, 71%) was prepared from 4-chlorophenol (0.70 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(4-chlorophenoxy)aniline (0.50 g, 65%) following general procedure B. N-[2-(4-Chlorophenoxy)phenyl]-N′-(thiazol-2-yl)urea (106 mg, 62%) was prepared from 2-(4-chlorophenoxy)aniline (109 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541373B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-45e0de64aa0a47bf97e09840614026cd |
| Source note | uspto-grants-2009_06 |