HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 1-(3-Methoxyphenoxy)-2-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | 3-Methoxyphenol | HCID 9007 | — |
| Reactant | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| Reactant | 2-(3-Methoxyphenoxy)aniline | HCID 13000272 | — |
| Product | 1-(3-Methoxyphenoxy)-2-nitrobenzene | HCID 9311137 | 69% |
| Product | N-[2-(3-Methoxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59733009 | 68% |
Reaction Steps
2-(3-Methoxyphenoxy)-1-nitrobenzene (0.84 g, 69%) was prepared from 3-methoxyphenol (0.68 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(3-methoxyphenoxy)aniline (0.51 g, 70%) following general procedure B. N-[2-(3-Methoxyphenoxy)phenyl]-N′-(thiazol-2-yl)urea (136 mg, 68%) was prepared from 2-(3-methoxyphenoxy)aniline (108 mg, 0.5 mmol) and 2-amino-thiazole (60 mg, 0.6 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541373B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-e650ddd96ca34882bd08bad5706fb73c |
| Source note | uspto-grants-2009_06 |