HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → HCID 66998218, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| Reactant | 2-Fluoro-6-methoxyphenol | HCID 2737367 | — |
| Reactant | 2-(2-Fluoro-6-methoxyphenoxy)aniline | HCID 66999003 | — |
| Product | 1-(Thiazol-2-yl)urea | HCID 16781708 | 63% |
| Product | HCID 66998218 | HCID 66998218 | 64% |
Reaction Steps
2-(2-Fluoro-6-methoxyphenoxy)-1-nitrobenzene (0.84 g, 64%) was prepared from 2-fluoro-6-methoxyphenol (0.78 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(2-fluoro-6-methoxyphenoxy)-aniline (0.63 g, 85%) following general procedure C. N-2-(2-Fluoro-6-methoxyphenoxy)-phenyl)-N′-(thiazol-2-yl)urea (114 mg, 63%) was prepared from 2-(2-fluoro-6-methoxyphenoxy)aniline (117 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541373B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-2152dd8b9f0341d395a6553d803a9654 |
| Source note | uspto-grants-2009_06 |