HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 2-(2,4,6-Trifluorophenoxy)-1-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| Reactant | 2,4,6-Trifluorophenol | HCID 519974 | — |
| Reactant | 2-(2,4,6-Trifluorophenoxy)aniline | HCID 66998613 | — |
| Product | N-[2-(2,4,6-Trifluorophenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732712 | 60% |
| Product | 2-(2,4,6-Trifluorophenoxy)-1-nitrobenzene | HCID 66998973 | 85% |
Reaction Steps
2-(2,4,6-Trifluorophenoxy)-1-nitrobenzene (1.14 g, 85%) was prepared from 2,4,6-trifluorophenol (0.74 g, 5.0 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(2,4,6-trifluorophenoxy)aniline (0.42 g, 70%, 2.5 mmol scale) following general procedure B. N-[2-(2,4,6-Trifluorophenoxy)phenyl]-N′-(thiazol-2-yl)urea (219 mg, 60%) was prepared from 2-(2,4,6-trifluorophenoxy)aniline (237 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541373B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-8738d35063514d23bca53161eb0fc1c9 |
| Source note | uspto-grants-2009_06 |