HuagongsheHuagongshe Chemistry Print Report · For research reference only
Guaiacol → HCID 27815639, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Guaiacol | HCID 460 | — |
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | 4-Fluoro-3-nitrobenzonitrile | HCID 2774654 | — |
| Reactant | HCID 43518248 | HCID 43518248 | — |
| Product | HCID 27815639 | HCID 27815639 | 81% |
| Product | N-[5-Cyano-2-(2-methoxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732835 | 71% |
Reaction Steps
4-(2-Methoxyphenoxy)-3-nitrobenzonitrile (1.10 g, 81%) was prepared from 2-methoxyphenol (0.68 g, 5.5 mmol) and 4-fluoro-3-nitrobenzonitrile (1.33 g, 5.0 mmol) following general procedure A. This was reduced to 4-(2-methoxyphenoxy)-3-aminobenzonitrile (0.62 g, 63%) following general procedure B. N-[5-Cyano-2-(2-methoxyphenoxy)-phenyl]-N′-(thiazol-2-yl)urea (130 mg, 71%) was prepared from 4-(2-methoxyphenoxy)-3-aminobenzonitrile (120 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541373B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-e64baed2c82b4e7085ca9e65d9835394 |
| Source note | uspto-grants-2009_06 |