HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 5-Fluoro-2-(2-methylsulfanylphenoxy)-1-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | o-(Methylthio)phenol | HCID 61261 | — |
| Reactant | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| Reactant | 5-Fluoro-2-(2-methylsulfanylphenoxy)aniline | HCID 63648471 | — |
| Product | N-[5-Fluoro-2-(2-methylsulfanylphenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732844 | 65% |
| Product | 5-Fluoro-2-(2-methylsulfanylphenoxy)-1-nitrobenzene | HCID 66998972 | 68% |
Reaction Steps
5-Fluoro-2-(2-methylsulfanylphenoxy)-1-nitrobenzene (0.95 g, 68%) was prepared from 2-hydroxythioanisole (0.77 g, 5.5 mmol) and 2,5-difluoro-1-nitrobenzene (0.80 g, 5.0 mmol) following the general procedure A. This was reduced to 5-fluoro-2-(2-methylsulfanyl-phenoxy)aniline (0.52 g, 62%) following general procedure B. N-[5-Fluoro-2-(2-methylsulfanylphenoxy)phenyl]-N′-(thiazol-2-yl)urea (120 mg, 65%) was prepared from 5-fluoro-2-(2-methylsulfanylphenoxy)aniline (125 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541373B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-8b6c31eebb664b85bdb4efd3876f72ba |
| Source note | uspto-grants-2009_06 |