HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → N-[2-(2,3-dimethoxyphenoxy)-4-fluorophenyl]-N'-(thiazol-2-yl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | 2,4-Difluoronitrobenzene | HCID 67967 | — |
| Reactant | 2,3-Dimethoxyphenol | HCID 78828 | — |
| Reactant | 2-(2,3-Dimethoxyphenoxy)-4-fluoroaniline | HCID 66999039 | — |
| Product | N-[2-(2,3-dimethoxyphenoxy)-4-fluorophenyl]-N'-(thiazol-2-yl)urea | HCID 59732915 | 60% |
| Product | 2-(2,3-Dimethoxyphenoxy)-4-fluoro-1-nitrobenzene | HCID 66999043 | 60% |
Reaction Steps
2-(2,3-Dimethoxyphenoxy)-4-fluoro-1-nitrobenzene (0.88 g, 60%) was prepared from 2,3-dimethoxyphenol (0.85 g, 5.5 mmol) and 2,4-difluoro-1-nitrobenzene (0.8 g, 5.0 mmol) following the general procedure F. This compound was reduced to 2-(2,3-dimethoxyphenoxy)-4-fluoroaniline (0.52 g, 66%) following the general procedure C. N-[2-(2,3-dimethoxyphenoxy)-4-fluorophenyl]-N′-(thiazol-2-yl)urea (116 mg, 60%) was prepared from 2-(2,3-dimethoxyphenoxy)-4-fluoroaniline (132 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541373B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-2b41b46665fd4511a016c69715a5d896 |
| Source note | uspto-grants-2009_06 |