HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 3-(2,3-Dimethoxyphenoxy)-4-nitrotoluene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| Reactant | 2,3-Dimethoxyphenol | HCID 78828 | — |
| Reactant | 2-(2,3-Dimethoxyphenoxy)-4-methylaniline | HCID 66998836 | — |
| Product | N-[2-(2,3-Dimethoxyphenoxy)-4-methylphenyl]-N'-(thiazol-2-yl)urea | HCID 59733062 | 63% |
| Product | 3-(2,3-Dimethoxyphenoxy)-4-nitrotoluene | HCID 66998924 | 64% |
Reaction Steps
3-(2,3-Dimethoxyphenoxy)-4-nitrotoluene (0.92 g, 64%) was prepared from 2,3-dimethoxyphenol (0.85 g, 5.5 mmol) and 3-fluoro-4-nitrotoluene (0.78 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(2,3-dimethoxyphenoxy)-4-methylaniline (0.65 g, 79%) following general procedure C. N-[2-(2,3-Dimethoxyphenoxy)-4-methylphenyl]-N′-(thiazol-2-yl)urea (120 mg, 63%) was prepared from 2-(2,3-dimethoxyphenoxy)-4-methylaniline (130 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541373B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-e5dc8de24ac44e1eb27e6f1afb42c99c |
| Source note | uspto-grants-2009_06 |