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2-Aminothiazole → 1-(Cyclopentyloxy)-2-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | Cyclopentanol | HCID 7298 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | 2-(Cyclopentyloxy)aniline | HCID 6485398 | — |
| 生成物 | 1-(Cyclopentyloxy)-2-nitrobenzene | HCID 22164473 | 80% |
| 生成物 | N-(2-Cyclopentyloxyphenyl)-N'-(thiazol-2-yl)urea | HCID 59732940 | 70% |
反応手順
2-(Cyclopentyloxy)-1-nitrobenzene (1.04 g, 80%) was prepared from cyclopentanol (0.46 ml, 5.0 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure G. This was reduced to 2-(cyclopentyloxy)aniline (0.30 g, 68%, 2.5 mmol scale) following general procedure B. N-(2-Cyclopentyloxyphenyl)-N′-(thiazol-2-yl)urea (212 mg, 70%) was prepared from 2-(cyclopentyloxy)aniline (177 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07541373B2 |
| 出典データセット | uspto-grants-2009_06 |
| ORD ID | ord-bd3386ccbfb24114a03cc7dfff7ab811 |
| 出典メモ | uspto-grants-2009_06 |