HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 2-(Cyclopentylmethoxy)-1-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| Reactant | Cyclopentanemethanol | HCID 77195 | — |
| Reactant | 2-(Cyclopentylmethoxy)aniline | HCID 19754712 | — |
| Product | N-[2-(Cyclopentylmethoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732720 | 60% |
| Product | 2-(Cyclopentylmethoxy)-1-nitrobenzene | HCID 66998904 | 80% |
Reaction Steps
2-(Cyclopentylmethoxy)-1-nitrobenzene (443 mg, 80%) was prepared from cyclopentanemethanol (0.32 ml, 3.0 mmol) and 1-fluoro-2-nitrobenzene (0.36 g, 2.5 mmol) following the general procedure G. This was reduced to 2-(cyclopentylmethoxy)aniline (268 mg, 70%) following general procedure B. N-[2-(Cyclopentylmethoxy)phenyl]-N′-(thiazol-2-yl)-urea (286 mg, 60%) was prepared from 2-(cyclopentylmethoxy)aniline (0.25 g, 1.5 mmol) and 2-aminothiazole (150 mg, 1.5 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541373B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-902e20b219d74a34922371d0ffeee8a1 |
| Source note | uspto-grants-2009_06 |