HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1983308Generated: October 30, 2026
Diisopropylethylamine → HCID 178426625, compound
https://huagongshe.com/reaction/1983308
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Pyrrole-1-carboxamidine | HCID 20619376 | — |
| Reactant | 1-(4-Aminomethyl-thiazol-2-yl)-3-(2-cyclopentanecarbonyl-4-methylphenyl)-urea | HCID 59732816 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178426625 | HCID 178426625 | 88% |
Reaction Steps
To a solution of 1-(4-aminomethyl-thiazol-2-yl)-3-(2-cyclopentanecarbonyl-4-methylphenyl)-urea (90 mg, 0.25 mmol) in THF (10 mL) was added pyrrole-1-carboxamidine (54 mg, 0.50 mmol) and DIEA (90 μL). The reaction mixture was heated 60° C. for 3 h and concentrated. The crude product was purified by flash chromatography [silica, DCM:ethyl acetate (50:50 to 10:90)] to yield 1-(2-cyclopentanecarbonyl-4-methyl-phenyl)-3-(4-guanidinomethyl-thiazol-2-yl)-urea (88 mg, 88%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07541373B2 |
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| Source dataset | uspto-grants-2009_06 |
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| ORD ID | ord-1ec6fe4d9ce74775957564911dbe2d02 |
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| Source note | uspto-grants-2009_06 |
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