Succinic anhydride → HCID 86593073, compound

HRID 1983326Notes

Reaction equation

HRID 1983326 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[N:5]=[C:6]([NH:9][C:10]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][C:14]=2[C:20]([CH:22]2[CH2:26][CH2:25][CH2:24][CH2:23]2)=[O:21])=[O:11])[S:7][CH:8]=1.C1(=O)[O:32][C:30](=[O:31])[CH2:29][CH2:28]1>C(Cl)Cl>[CH:22]1([C:20]([C:14]2[CH:15]=[C:16]([CH3:19])[CH:17]=[CH:18][C:13]=2[NH:12][C:10](=[O:11])[NH:9][C:6]2[S:7][CH:8]=[C:4]([CH2:3][CH2:2][NH:1][CH2:28][CH2:29][C:30]([OH:32])=[O:31])[N:5]=2)=[O:21])[CH2:23][CH2:24][CH2:25][CH2:26]1

Participants

4

Reactant 2

HCID 7922Succinic anhydrideHCID 59732818HCID 59732818, compound

Product 1

HCID 86593073HCID 86593073, compoundYield 56.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-[4-(amino-ethyl)-thiazol-2-yl]-3-(2-cyclopentanecarbonyl-4-methyl-phenyl)-urea (0.03 g, 0.08 mmol) and succinic anhydride (0.02 g, 0.16 mmol) in 10 mL DCM were refluxed for 2 h. Reaction was concentrated and purified on silica gel using 5% MeOH/EtOAc to yield the pure product (20 mg, 53%).

Workup

  1. customReaction
  2. concentrationwas concentrated
  3. custompurified on silica gel using 5% MeOH/EtOAc

Sources & evidence

ORD record
ord-369939c8061e47eba1f244b99d1131fc
Source dataset
uspto-grants-2009_06
Patent number
US07541373B2

Reaction notes

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