N,N-Dimethylglycine → HCID 59733124, compound

HRID 1983331Notes

Reaction equation

HRID 1983331 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[N:5]=[C:6]([NH:9][C:10]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][C:14]=2[C:20]([CH:22]2[CH2:26][CH2:25][CH2:24][CH2:23]2)=[O:21])=[O:11])[S:7][CH:8]=1.[CH3:27][N:28]([CH2:30][C:31](O)=[O:32])[CH3:29]>>[CH:22]1([C:20]([C:14]2[CH:15]=[C:16]([CH3:19])[CH:17]=[CH:18][C:13]=2[NH:12][C:10](=[O:11])[NH:9][C:6]2[S:7][CH:8]=[C:4]([CH2:3][CH2:2][NH:1][C:31](=[O:32])[CH2:30][N:28]([CH3:29])[CH3:27])[N:5]=2)=[O:21])[CH2:23][CH2:24][CH2:25][CH2:26]1

Participants

3

Reactant 2

HCID 673N,N-DimethylglycineHCID 59732818HCID 59732818, compound

Product 1

HCID 59733124HCID 59733124, compoundYield 62.2%

Procedure

N-(2-{-2-[3-(2-Cyclopentanecarbonyl-4-methyl-phenyl)-ureido]-thiazol-4-yl}-ethyl)-2-dimethylamino acetamide (37 mg, 61%) was prepared from 1-[4-(amino-ethyl)-thiazol-2-yl]-3-(2-cyclopentanecarbonyl-4-methyl-phenyl)-urea (0.05 g, 0.13 mmol), dimethylamino acetic acid (0.02 g, 0.13 mmol) following the general procedure K.

Sources & evidence

ORD record
ord-128fb964890541c8b8a1dabde4a9b814
Source dataset
uspto-grants-2009_06
Patent number
US07541373B2

Reaction notes

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