HCID 12782766, compound → HCID 59733008, compound

HRID 1983356Notes

Reaction equation

HRID 1983356 reaction equation
Br[C:2]1[S:6][C:5]([NH:7][C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][C:12]=2[C:18]([CH:20]2[CH2:24][CH2:23][CH2:22][CH2:21]2)=[O:19])=[O:9])=[N:4][CH:3]=1.[CH3:25][O:26][C:27]([C:29]1[C:34]([SH:35])=[CH:33][CH:32]=[CH:31][N:30]=1)=[O:28]>>[CH3:25][O:26][C:27]([C:29]1[C:34]([S:35][C:2]2[S:6][C:5]([NH:7][C:8]([NH:10][C:11]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][C:12]=3[C:18]([CH:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)=[O:19])=[O:9])=[N:4][CH:3]=2)=[CH:33][CH:32]=[CH:31][N:30]=1)=[O:28]

Participants

3

Reactant 2

HCID 12782766HCID 12782766, compoundHCID 597327971-(5-Bromothiazol-2-yl)-3-(2-cyclopentanecarbonyl-4-methyl-phenyl)-urea

Product 1

HCID 59733008HCID 59733008, compoundYield 30%

Procedure

3-{2-[3-(2-Cyclopentanecarbonyl-4-methyl-phenyl)-ureido]-thiazol-5-ylsulfanyl}-pyridine-2-carboxylic acid methyl ester (149 mg, 30%) was prepared from 1-(5-bromo-thiazol-2-yl)-3-(2-cyclo pentanecarbonyl-4-methyl-phenyl)-urea (408 mg, 1 mmol) and 3-mercapto-pyridine-2-carboxylic acid methyl ester (340 mg, 2 mmol) following the general procedure Q.

Sources & evidence

ORD record
ord-1012ae3c1db84ccbb7255f5248bf6cdb
Source dataset
uspto-grants-2009_06
Patent number
US07541373B2

Reaction notes

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