HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 1-[2-(2-Methoxy-benzoyl)-5-methyl-phenyl]-3-thiazol-2-yl-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | 4-Methylanthranilic acid | HCID 75316 | — |
| Reactant | (2-Amino-4-methyl-phenyl)-(2-methoxy-phenyl)-methanone | HCID 66998866 | — |
| Product | 1-[2-(2-Methoxy-benzoyl)-5-methyl-phenyl]-3-thiazol-2-yl-urea | HCID 59732938 | 70% |
| Product | (2-Amino-4-methyl-phenyl)-(2-methoxy-phenyl)-methanone | HCID 66998866 | 30% |
Reaction Steps
(2-Amino-4-methyl-phenyl)-(2-methoxy-phenyl)-methanone (723 g, 30%) was prepared from 2-amino-4-methyl-benzoic acid (1.51 g, 10 mmol) following the general procedure S. 1-[2-(2-methoxy-benzoyl)-5-methyl-phenyl]-3-thiazol-2-yl-urea (129 mg, 70%) was prepared from (2-amino-4-methyl-phenyl)-(2-methoxy-phenyl)-methanone (121 mg, 0.5 mmol) and 2-aminothiazole (0.060 g, 0.6 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541373B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-3ffb74e477ae465289e224f21de602a5 |
| Source note | uspto-grants-2009_06 |