2-(Methylsulfonyl)ethanamine → HCID 59732981, compound

HRID 1983376Notes

Reaction equation

HRID 1983376 reaction equation
[CH3:1][O:2][C:3]1[CH:30]=[CH:29][CH:28]=[CH:27][C:4]=1[C:5]([C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][C:8]=1[NH:14][C:15](=[O:26])[NH:16][C:17]1[S:18][CH:19]=[C:20]([CH2:22][C:23]([OH:25])=O)[N:21]=1)=[O:6].[CH3:31][S:32]([CH2:35][CH2:36][NH2:37])(=[O:34])=[O:33]>>[CH3:31][S:32]([CH2:35][CH2:36][NH:37][C:23](=[O:25])[CH2:22][C:20]1[N:21]=[C:17]([NH:16][C:15]([NH:14][C:8]2[CH:9]=[C:10]([CH3:13])[CH:11]=[CH:12][C:7]=2[C:5](=[O:6])[C:4]2[CH:27]=[CH:28][CH:29]=[CH:30][C:3]=2[O:2][CH3:1])=[O:26])[S:18][CH:19]=1)(=[O:34])=[O:33]

Participants

3

Reactant 2

HCID 43405612-(Methylsulfonyl)ethanamineHCID 59732776HCID 59732776, compound

Product 1

HCID 59732981HCID 59732981, compoundYield 68.2%

Procedure

N-(2-Methanesulfonyl-ethyl)-2-(2-{3-[2-(2-methoxy-benzoyl)-5-methyl-phenyl]-ureido}-thiazol-4-yl)-acetamide (181 mg, 68%) was prepared from (2-{3-[2-(2-methoxy-benzoyl)-5-methyl-phenyl]-ureido}-thiazol-4-yl)-acetic acid (213 mg, 0.5 mmol) and 2-methanesulfonyl-ethylamine (61 mg, 0.5 mmol) following the general procedure K.

Sources & evidence

ORD record
ord-0ccf746b975d455a82dcc3629ba7a741
Source dataset
uspto-grants-2009_06
Patent number
US07541373B2

Reaction notes

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