HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 2-(Allyloxy)-4-methyl-1-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Allyl Alcohol | HCID 7858 | — |
| Reactant | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| Reactant | 4-Methyl-2-(2-methylpropoxy)aniline | HCID 24693559 | — |
| Reactant | 4-Methyl-2-[(prop-2-en-1-yl)oxy]aniline | HCID 39235899 | — |
| Product | 2-(Allyloxy)-4-methyl-1-nitrobenzene | HCID 13575666 | 70% |
| Product | 1-(2-Allyloxy-4-methyl-phenyl)-3-thiazol-2-yl-urea | HCID 59732961 | 68% |
Reaction Steps
3-Allyloxy-4-nitrotoluene (0.67 g, 70%) was prepared from allyl alcohol and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 4-methyl-2-(allyloxy)aniline (0.40 g, 70%) following general procedure B. 1-(2-Allyloxy-4-methyl-phenyl)-3-thiazol-2-yl-urea (196 mg, 68%) was prepared from 4-methyl-2-(2-methylpropoxy)aniline (163 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541373B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-4f2042c905f84fa19bd5ca13b6bfb9ad |
| Source note | uspto-grants-2009_06 |