HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 1-(2-Isopropoxy-4-methyl-phenyl)-3-thiazol-2-yl-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| Reactant | 4-Methyl-2-(propan-2-yloxy)aniline | HCID 15068114 | — |
| Product | 1-(2-Isopropoxy-4-methyl-phenyl)-3-thiazol-2-yl-urea | HCID 59732928 | 62% |
Reaction Steps
3-(2-Isopropoxy)-4-nitrotoluene (0.72 g, 74%) was prepared from 2-propanol and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 2-isopropoxy-4-methyl-aniline (0.42 g, 70%) following general procedure C. 1-(2-Isopropoxy-4-methyl-phenyl)-3-thiazol-2-yl-urea (180 mg, 62%) was prepared from 2-isopropoxy-4-methyl-aniline (165 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541373B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-2fbe04104ce949a38aa505ad87c252bc |
| Source note | uspto-grants-2009_06 |