HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → HCID 59732812, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Tetrahydropyran-2-methanol | HCID 7524 | — |
| Reactant | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| Reactant | 4-Methyl-2-(tetrahydro-2H-pyran-2-ylmethoxy)-phenylamine | HCID 43591698 | — |
| Product | HCID 59732812 | HCID 59732812 | 71% |
| Product | Tetrahydro-2-[(5-methyl-2-nitrophenoxy)methyl]-2H-pyran | HCID 66999100 | 64% |
Reaction Steps
4-Nitro-3-(tetrahydro-pyran-2-ylmethoxy)-toluene (0.80 g, 64%) was prepared from tetrahydropyran-2-ylmethanol and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 4-methyl-2-(tetrahydro-pyran-2-ylmethoxy)-aniline (0.50 g, 71%) following general procedure C. 1-[4-Methyl-2-(tetrahydro-pyran-2-ylmethoxy)-phenyl]-3-thiazol-2-yl-urea (246 mg, 71%) was prepared from 4-methyl-2-(tetrahydro-pyran-2-ylmethoxy)-aniline (221 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541373B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-efec5220cdb94e2396144fc2bc47a617 |
| Source note | uspto-grants-2009_06 |