HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 1-Fluoro-4-(2-methylpropoxy)-2-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Isobutanol | HCID 6560 | — |
| Reactant | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| Reactant | 5-Fluoro-2-(2-methylpropoxy)aniline | HCID 28412216 | — |
| Product | HCID 59733029 | HCID 59733029 | 72% |
| Product | 1-Fluoro-4-(2-methylpropoxy)-2-nitrobenzene | HCID 66998932 | 78% |
Reaction Steps
5-Fluoro-2-(2-methylpropoxy)-4-nitrobenzene (0.83 g, 78%) was prepared from 2-methylpropanol (0.46 ml, 5.0 mmol) and 2,5-difluoro-4-nitrobenzene (0.80 g, 5.0 mmol) following the general procedure G. This was reduced to 5-fluoro-2-(2-methylpropoxy)-aniline (0.58 g, 81%) following general procedure C. 1-(5-Fluoro-2-isobutoxy-phenyl)-3-thiazol-2-yl-urea (220 mg, 72%) was prepared from 5-fluoro-2-(2-methylpropoxy)-aniline (183 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07541373B2 |
| Source dataset | uspto-grants-2009_06 |
| ORD ID | ord-284963f72f0543eaa1045c435a419122 |
| Source note | uspto-grants-2009_06 |