2,4-Dichloro-5-fluoropyrimidine → 2-chloro-N4-[3-[[4-(ethoxycarbonyl)piperidino]methyl]phenyl]-5-fluoro-4-pyrimidineamine

HRID 198347Notes

Reaction equation

HRID 198347 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([F:9])[c:6]([Cl:8])[n:7]1.[NH2:10][c:11]1[cH:12][c:13]([CH2:14][N:15]2[CH2:16][CH2:17][CH:18]([C:21](=[O:22])[O:23][CH2:24][CH3:25])[CH2:19][CH2:20]2)[cH:26][cH:27][cH:28]1>>[Cl:1][c:2]1[n:3][cH:4][c:5]([F:9])[c:6]([NH:10][c:11]2[cH:12][c:13]([CH2:14][N:15]3[CH2:16][CH2:17][CH:18]([C:21](=[O:22])[O:23][CH2:24][CH3:25])[CH2:19][CH2:20]3)[cH:26][cH:27][cH:28]2)[n:7]1

Participants

3

Reactant 2

HCID 2507052,4-Dichloro-5-fluoropyrimidineHCID 2800723Ethyl 1-(3-Aminobenzyl)Piperidine-4-Carboxylate

Product 1

HCID 220606772-chloro-N4-[3-[[4-(ethoxycarbonyl)piperidino]methyl]phenyl]-5-fluoro-4-pyrimidineamine

Sources & evidence

ORD record
ord-c811de980ba245b383a3c5199a8cb97d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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